PARVA and ERO1B

Data Source:
BioGRID (two hybrid)

		PARVA	ERO1B
Description		parvin alpha	endoplasmic reticulum oxidoreductase 1 beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Thiol Oxidase Activity Unfolded Protein Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Protein Folding Protein Phosphopantetheinylation Protein Folding In Endoplasmic Reticulum
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Insulin processing
Drugs			1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)
Interacting Genes		14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1	3 interacting genes: BRCA1 ERP44 P4HB
Entrez ID		55742	56605
HPRD ID		16283	13279
Ensembl ID		ENSG00000197702	ENSG00000086619
Uniprot IDs		Q9NVD7	Q86YB8
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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