N4BP2 and TOLLIP

Data Source:
BioGRID (two hybrid)

		N4BP2	TOLLIP
Description		NEDD4 binding protein 2	toll interacting protein
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Cytoplasm Cytosol Nuclear Body Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Endonuclease Activity Protein Binding ATP Binding Ubiquitin Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding
	Biological Process	Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Neutrophil Degranulation Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways			Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Platelet thrombus formation ( 22550155)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		5 interacting genes: BCL3 CREBBP EP300 NEDD4 TOLLIP	78 interacting genes: ACTN2 ARRDC3 ATXN1 BHLHE40 C19orf54 CDIP1 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 EIF2AK2 FAM166B FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TOM1L2 TTC9C UBC USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19 ZRANB1
Entrez ID		55728	54472
HPRD ID		11382	05887
Ensembl ID		ENSG00000078177	ENSG00000078902
Uniprot IDs		B2ZZ87 Q86UW6	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		2D9I 2VKC 3BHB 3FAU	1WGL 2N31
Enriched GO Terms of Interacting Partners?
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