TOLLIP and TOM1L2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TOLLIP	TOM1L2
Description		toll interacting protein	target of myb1 like 2 membrane trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Nuclear Body Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Endosome Membrane Extracellular Exosome
	Molecular Function	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Neutrophil Degranulation Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division
Pathways		Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)	Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378)
Interacting Genes		78 interacting genes: ACTN2 ARRDC3 ATXN1 BHLHE40 C19orf54 CDIP1 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 EIF2AK2 FAM166B FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TOM1L2 TTC9C UBC USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19 ZRANB1	11 interacting genes: APP FAM9B LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 SMURF1 TOLLIP UBC WBP2
Entrez ID		54472	146691
HPRD ID		05887	18213
Ensembl ID		ENSG00000078902	ENSG00000175662
Uniprot IDs		B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2	B7Z2U2 B7Z671 F5H3S6 Q6ZVM7
PDB IDs		1WGL 2N31
Enriched GO Terms of Interacting Partners?
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