DOCK10 and RHOJ

Data Source:
HPRD (in vitro)

		DOCK10	RHOJ
Description		dedicator of cytokinesis 10	ras homolog family member J
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendritic Spine Extracellular Exosome	Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Molecular_function Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase Mediated Signal Transduction Regulation Of Cell Migration Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis	Angiogenesis Endocytosis Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cdc42 Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		Factors involved in megakaryocyte development and platelet production	Rho GTPase cycle
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CCDC102B LURAP1 MAGEA11 RHOJ	25 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL ZNF426
Entrez ID		55619	57381
HPRD ID		10919	09632
Ensembl ID		ENSG00000135905	ENSG00000126785
Uniprot IDs		Q96BY6	A0A024R692 Q7Z513 Q9H4E5
PDB IDs		6TKY 6TKZ 6TM1
Enriched GO Terms of Interacting Partners?
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