OTUB1 and UBE4B

Data Source:
BioGRID (enzymatic study)

		OTUB1	UBE4B
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	ubiquitination factor E4B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding
	Biological Process	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein Phosphopantetheinylation Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Atrial fibrillation ( 29892015) Hepatocellular carcinoma ( 20676096) Resting heart rate ( 27798624)
Interacting Genes		55 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28	22 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		55611	10277
HPRD ID		08493	11659
Ensembl ID		ENSG00000167770	ENSG00000130939
Uniprot IDs		B3KUV5 Q96FW1	O95155
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?
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