PPP1R9A and RPS6KA1

Data Source:
BioGRID (unspecified method)

		PPP1R9A	RPS6KA1
Description		protein phosphatase 1 regulatory subunit 9A	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuromuscular Junction Neuronal Cell Body Dendritic Spine Neck Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Growth Cone Lamellipodium	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding GTPase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Actin Filament Organization Aging Positive Regulation Of Neuron Projection Development Calcium-mediated Signaling Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Protein Kinase Activity Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Synapse Structural Plasticity Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Toxic Substance Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Spontaneous Neurotransmitter Secretion	Apoptotic Process Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Purvalanol A Fostamatinib
Diseases
GWAS		Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Waist circumference ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ACTG1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2	86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		55607	6195
HPRD ID		16000	03402
Ensembl ID		ENSG00000158528	ENSG00000117676
Uniprot IDs		A4D1I0 B7ZLX4 Q9ULJ8	Q15418
PDB IDs		1WF8	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY
Enriched GO Terms of Interacting Partners?
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