Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RPS6KA1 and YBX1
Data Source:
BioGRID
(enzymatic study)
RPS6KA1
YBX1
Description
ribosomal protein S6 kinase A1
Y-box binding protein 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Region
Nucleus
Nucleoplasm
U12-type Spliceosomal Complex
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Extracellular Exosome
CRD-mediated MRNA Stability Complex
Histone Pre-mRNA 3'end Processing Complex
Messenger Ribonucleoprotein Complex
Ribonucleoprotein Complex
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Nucleic Acid Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Binding
MiRNA Binding
GTPase Binding
C5-methylcytidine-containing RNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Apoptotic Process
Cell Cycle
Signal Transduction
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Growth
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Translation In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
MRNA Splicing, Via Spliceosome
Regulation Of Transcription, DNA-templated
Notch Signaling Pathway
Epidermis Development
Regulation Of Gene Expression
Negative Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Stabilization
Embryonic Morphogenesis
RNA Transport
TRNA Transport
Positive Regulation Of Cell Division
CRD-mediated MRNA Stabilization
Protein Localization To Cytoplasmic Stress Granule
MiRNA Transport
Negative Regulation Of Cellular Senescence
Pathways
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Noncanonical activation of NOTCH3
Drugs
Purvalanol A
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Interacting Genes
86 interacting genes:
ARHGEF11
ARHGEF12
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RPTOR
SHANK3
SHROOM2
SLC9A3R2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
116 interacting genes:
ACTA2
AKT1
ANKRD2
APBB1
CALM1
CASP8
CSNK2A1
CTCF
DUX4
FBXO33
FMR1
FUS
GSK3B
H1-2
HABP4
HLA-C
HNRNPD
HNRNPK
IL7R
IREB2
IRF1
JAM2
LCP2
LSM3
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYC
MYCN
NFYB
PCBP2
PCNA
PRPF40A
PURA
RBBP6
RPS6KA1
RPS6KA3
SLC6A4
SMAD3
SMU1
SREK1
SRSF9
TFAP2A
TP53
TRAF6
VEGFA
Entrez ID
6195
4904
HPRD ID
03402
01095
Ensembl ID
ENSG00000117676
ENSG00000065978
Uniprot IDs
Q15418
P67809
PDB IDs
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
1H95
5YTS
5YTT
5YTV
5YTX
6A6L
6KTC
6KUG
6LMR
6LMS
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?