NAGK and SPRED1

Data Source:
BioGRID (two hybrid)

		NAGK	SPRED1
Description		N-acetylglucosamine kinase	sprouty related EVH1 domain containing 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle
	Molecular Function	Protein Binding ATP Binding N-acetylglucosamine Kinase Activity	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation	MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs		N-Acetylglucosamine
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Erythema nodosum in inflammatory bowel disease ( 24487271)	Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		33 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DYNC1I1 GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	37 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655
Entrez ID		55577	161742
HPRD ID		08441	11601
Ensembl ID		ENSG00000124357	ENSG00000166068
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	Q7Z699
PDB IDs		2CH5 2CH6	3SYX 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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