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CDCA7L and MLH1
Data Source:
BioGRID
(two hybrid, two hybrid)
CDCA7L
MLH1
Description
cell division cycle associated 7 like
mutL homolog 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Late Recombination Nodule
Membrane
Mismatch Repair Complex
MutLalpha Complex
Molecular Function
Protein Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Biological Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Meiotic Telomere Clustering
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Drugs
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Endometrial Cancer
Ovarian cancer
GWAS
Breast cancer (
29059683
)
Height (
20189936
)
Multiple myeloma (
26007630
)
Multiple myeloma and monoclonal gammopathy (
26007630
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Squamous cell lung carcinoma (
28604730
)
Urate levels in obese individuals (
25811787
)
Autism spectrum disorder or schizophrenia (
28540026
)
Platelet distribution width (
32888494
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
68 interacting genes:
ABT1
ANKRD1
ANKRD11
ANKRD23
AVPI1
AXIN1
BAG5
BEND7
BHLHB9
BRPF1
BYSL
CARD9
CAVIN1
CCDC116
CCDC33
CEP70
CTNNBL1
DAXX
DEDD2
DMAP1
EIF4A3
FAM217B
FAM9B
GOLGA2
HSF2BP
ING5
JADE2
KRTAP10-7
LMO1
MCRS1
MDFI
MEOX2
MFAP1
MLH1
MORN3
MRPL28
MYC
NDUFB7
NOL12
NOP2
PBX1
PBX2
PICK1
PIH1D1
PIP4K2B
PPP1R16A
PPP1R16B
PRDM14
PRPF31
RRP7A
SNRNP48
SSX1
SSX2IP
STX11
SUV39H1
TADA2A
TFPT
TNNI1
TRAF3IP3
TRIM42
UBL4A
UTP3
VDR
ZGPAT
ZNF250
ZNF438
ZNF620
ZNF821
139 interacting genes:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FAN1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NFIX
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
U2AF1L5
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
Entrez ID
55536
4292
HPRD ID
11481
00390
Ensembl ID
ENSG00000164649
ENSG00000076242
Uniprot IDs
A0A024RA51
A8K8X5
Q96GN5
A0A024R2S9
P40692
Q59EG3
PDB IDs
5YI9
6EMO
3RBN
4P7A
5U5P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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