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MLH1 and LY96
Data Source:
BioGRID
(two hybrid)
MLH1
LY96
Description
mutL homolog 1
lymphocyte antigen 96
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Late Recombination Nodule
Membrane
Mismatch Repair Complex
MutLalpha Complex
Extracellular Space
Plasma Membrane
Endosome Membrane
Intrinsic Component Of Plasma Membrane
Lipopolysaccharide Receptor Complex
Molecular Function
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Lipopolysaccharide Binding
Lipopolysaccharide Immune Receptor Activity
Protein Binding
Coreceptor Activity
Toll-like Receptor 4 Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Meiotic Telomere Clustering
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cellular Defense Response
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Response To Lipopolysaccharide
Detection Of Lipopolysaccharide
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
ER-Phagosome pathway
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Morphine
(R)-3-hydroxytetradecanoic acid
Lauric acid
Myristic acid
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Endometrial Cancer
Ovarian cancer
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Platelet distribution width (
32888494
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Blood protein levels (
29875488
)
Carotid plaque burden (smoking interaction) (
24954085
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Postoperative atrial fibrillation in coronary artery bypass grafting surgery (
26385043
)
Interacting Genes
139 interacting genes:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FAN1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NFIX
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
U2AF1L5
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
8 interacting genes:
CALM1
CDKN2C
LCN2
MESD
MLH1
SMARCB1
TLR2
TLR4
Entrez ID
4292
23643
HPRD ID
00390
05579
Ensembl ID
ENSG00000076242
ENSG00000154589
Uniprot IDs
A0A024R2S9
P40692
Q59EG3
Q9Y6Y9
PDB IDs
3RBN
4P7A
5U5P
1T2Z
2E56
2E59
2Z65
3FXI
3ULA
4G8A
Enriched GO Terms of Interacting Partners
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