MLH1 and ISY1

Data Source:
BioGRID (two hybrid)

		MLH1	ISY1
Description		mutL homolog 1	ISY1 splicing factor homolog
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GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex	Prp19 Complex Nucleus Nucleoplasm U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Post-spliceosomal Complex
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases		Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Platelet distribution width ( 32888494) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		139 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FAN1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH3 MSH4 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NFIX NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 U2AF1L5 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774	9 interacting genes: CCNC EXOC8 FAM90A1 KDM8 LMO1 LMO2 MLH1 WBP4 XAB2
Entrez ID		4292	57461
HPRD ID		00390	13834
Ensembl ID		ENSG00000076242	ENSG00000240682
Uniprot IDs		A0A024R2S9 P40692 Q59EG3	Q9ULR0
PDB IDs		3RBN 4P7A 5U5P	5YZG 6FF7 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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