RHOT1 and SHANK2

Data Source:
BioGRID (affinity chromatography technology)

		RHOT1	SHANK2
Description		ras homolog family member T1	SH3 and multiple ankyrin repeat domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Integral Component Of Mitochondrial Outer Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Molecular_function GTPase Activity Calcium Ion Binding Protein Binding GTP Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Mitochondrion Organization Regulation Of Mitochondrion Organization Protein Deubiquitination Cellular Homeostasis Establishment Of Mitochondrion Localization By Microtubule Attachment Regulation Of Neurotransmitter Secretion Mitochondrion Transport Along Microtubule Regulation Of Small GTPase Mediated Signal Transduction Mitochondrial Outer Membrane Permeabilization Regulation Of Organelle Transport Along Microtubule	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Rho GTPase cycle Ub-specific processing proteases	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Obesity-related traits ( 23251661)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes			19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		55288	22941
HPRD ID		15247	04479
Ensembl ID		ENSG00000126858	ENSG00000162105
Uniprot IDs		H7BXZ6 Q8IXI2	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs		5KSO 5KSP 5KSY 5KSZ 5KTY 5KU1 6D71
Enriched GO Terms of Interacting Partners?
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