SGO1 and PPP2R5B

Data Source:
HPRD (in vivo)

		SGO1	PPP2R5B
Description		shugoshin 1	protein phosphatase 2 regulatory subunit B'beta
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleoplasm Centrosome Cytosol	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Kinase Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Homologous Chromosome Segregation Meiotic Sister Chromatid Cohesion Cell Division Mitotic Sister Chromatid Cohesion, Centromeric	Protein Dephosphorylation Regulation Of Signaling Receptor Activity Positive Regulation Of Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Autophosphorylation IRE1-mediated Unfolded Protein Response Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of G0 To G1 Transition Positive Regulation Of Cell Cycle Arrest Cellular Response To Growth Factor Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Serum uric acid levels ( 32514006)
Interacting Genes		20 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6	7 interacting genes: AXIN1 CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1
Entrez ID		151648	5526
HPRD ID		12377	09038
Ensembl ID		ENSG00000129810	ENSG00000068971
Uniprot IDs		A0A024R2J4 B5BUA4 Q5FBB7	A0A024R593 Q15173
PDB IDs		3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?
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