PSPC1 and SFPQ

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PSPC1	SFPQ
Description		paraspeckle component 1	splicing factor proline and glutamine rich
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Speck Dendrite Cytoplasm Paraspeckles RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Regulation Of Transcription, DNA-templated Regulation Of Circadian Rhythm Innate Immune Response Negative Regulation Of Transcription, DNA-templated Rhythmic Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Activation Of Innate Immune Response Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Histone H3 Deacetylation Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways			PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
Drugs			Copper Artenimol
Diseases
GWAS		Waist circumference adjusted for body mass index ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Endometrial cancer ( 21499250) Hip circumference ( 28552196)
Interacting Genes		13 interacting genes: DISC1 ESR1 KRT31 KRTAP13-1 LRIF1 LZTS1 NONO NUDT21 SFPQ TCERG1 WBP4 ZRANB1 ZSCAN5B	103 interacting genes: APBB1 AR CSNK2A1 ERG ESR1 EXOSC5 FHL2 FUS GAS7 H3-4 JPT1 LAMTOR5 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NONO PIN1 PPARG PPP1CA PRPF40A PSPC1 PTBP1 RAC1 SIN3A SMAD5 SNRPA SREK1 TCERG1 TOP1 UBC UBE2I WBP4 ZMYM2
Entrez ID		55269	6421
HPRD ID		10172	07284
Ensembl ID		ENSG00000121390	ENSG00000116560
Uniprot IDs		Q8WXF1	A0A384N5Z8 P23246 Q86VG2
PDB IDs		3SDE 5IFN 5WPA	4WII 4WIJ 4WIK 5WPA 6NCQ 6OWJ
Enriched GO Terms of Interacting Partners?
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