ASXL2 and UBE2E1

Data Source:
BioGRID (enzymatic study)

		ASXL2	UBE2E1
Description		ASXL transcriptional regulator 2	ubiquitin conjugating enzyme E2 E1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Transcription, DNA-templated Animal Organ Morphogenesis Positive Regulation Of Lipid Storage Protein Deubiquitination Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Protein Ubiquitination Protein Phosphopantetheinylation Anaphase-promoting Complex-dependent Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		UCH proteinases	ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)	Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: APP MBD6 PRPF40A UBC UBE2E1 UBE2E2 UBE2E3	114 interacting genes: ARIH2 ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXL17 FBXO2 FBXO7 H3C1 H4C1 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA7 UBASH3B UBE2G1 UBE3A UBOX5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		55252	7324
HPRD ID		10676	04225
Ensembl ID		ENSG00000143970	ENSG00000170142
Uniprot IDs		Q76L83	A0A024R2K3 B7Z306 P51965
PDB IDs			1XR9 3BZH 4JJQ 5LBN 6FGA
Enriched GO Terms of Interacting Partners?
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