UBE2E1 and TRIM28

Data Source:
BioGRID (pull down)

		UBE2E1	TRIM28
Description		ubiquitin conjugating enzyme E2 E1	tripartite motif containing 28
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Protein Ubiquitination Protein Phosphopantetheinylation Anaphase-promoting Complex-dependent Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Ras Protein Signal Transduction Embryo Implantation Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus DNA Methylation Involved In Embryo Development Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		114 interacting genes: ARIH2 ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXL17 FBXO2 FBXO7 H3C1 H4C1 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA7 UBASH3B UBE2G1 UBE3A UBOX5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	76 interacting genes: CBX1 CBX3 CBX5 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 ESR1 FBP1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA6 MAGED1 MAPKAPK2 MCM3 MCM5 MCM6 MYB NPM1 NR3C1 NR4A1 NR4A3 NSMCE3 PCNA PFDN5 PPP2CA PTEN RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93
Entrez ID		7324	10155
HPRD ID		04225	03445
Ensembl ID		ENSG00000170142	ENSG00000130726
Uniprot IDs		A0A024R2K3 B7Z306 P51965	Q13263
PDB IDs		1XR9 3BZH 4JJQ 5LBN 6FGA	1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1
Enriched GO Terms of Interacting Partners?
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