PPP2R2B and TOP1

Data Source:
BioGRID (unspecified method)

		PPP2R2B	TOP1
Description		protein phosphatase 2 regulatory subunit Bbeta	DNA topoisomerase I
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton	Nuclear Chromosome P-body Fibrillar Center Nucleus Nucleoplasm Nucleolus Protein-DNA Complex Perikaryon
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Domain Specific Binding Supercoiled DNA Binding
	Biological Process	Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Peptidyl-serine Dephosphorylation	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Peptidyl-serine Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug
Pathways			SUMOylation of DNA replication proteins
Drugs			Irinotecan Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Alcohol dependence ( 19581569) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Night sleep phenotypes ( 27126917) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Schizophrenia ( 30285260) Urate levels in lean individuals ( 25811787)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: CDK1 CHEK2 KLHL15 RAC1 TOP1 TP53	60 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6
Entrez ID		5521	7150
HPRD ID		05059	00535
Ensembl ID		ENSG00000156475	ENSG00000198900
Uniprot IDs		Q00005	P11387 Q9BVT2
PDB IDs			1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?
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