TOP1 and PDE10A

Data Source:
BioGRID (unspecified method)

		TOP1	PDE10A
Description		DNA topoisomerase I	phosphodiesterase 10A
Image
GO Annotations	Cellular Component	Nuclear Chromosome P-body Fibrillar Center Nucleus Nucleoplasm Nucleolus Protein-DNA Complex Perikaryon	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Domain Specific Binding Supercoiled DNA Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Peptidyl-serine Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process
Pathways		SUMOylation of DNA replication proteins	cGMP effects G alpha (s) signalling events
Drugs		Irinotecan Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan	Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Mardepodect 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE PQ-10 Tofisopam Triflusal Trapidil
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528)	Age-related nuclear cataracts ( 24951543) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 28135244 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		60 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6	3 interacting genes: CASP3 TOP1 WDR3
Entrez ID		7150	10846
HPRD ID		00535	17828
Ensembl ID		ENSG00000198900	ENSG00000112541
Uniprot IDs		P11387 Q9BVT2	A0A1B1UZQ1 A0A1B1UZR0 Q9Y233
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6KO0 6KO1 6KZE 6MSA 6MSC
Enriched GO Terms of Interacting Partners?
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