PPP2R2B and KLHL15

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PPP2R2B	KLHL15
Description		protein phosphatase 2 regulatory subunit Bbeta	kelch like family member 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton	Nucleus Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Protein Binding
	Biological Process	Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Peptidyl-serine Dephosphorylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Alcohol dependence ( 19581569) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Night sleep phenotypes ( 27126917) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Schizophrenia ( 30285260) Urate levels in lean individuals ( 25811787)	Prostate-specific antigen levels ( 28139693)
Interacting Genes		6 interacting genes: CDK1 CHEK2 KLHL15 RAC1 TOP1 TP53	2 interacting genes: PPP2R2B RBBP8
Entrez ID		5521	80311
HPRD ID		05059	09957
Ensembl ID		ENSG00000156475	ENSG00000174010
Uniprot IDs		Q00005	Q96M94 V9HWF1
PDB IDs
Enriched GO Terms of Interacting Partners?
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