PPP1CB and TLX1

Data Source:
HPRD (in vitro, two hybrid)

		PPP1CB	TLX1
Description		protein phosphatase 1 catalytic subunit beta	T cell leukemia homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Glycogen Granule Extracellular Exosome PTW/PP1 Phosphatase Complex	Chromatin Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Cell Division	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development
Pathways		Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation Signaling by MRAS-complex mutants
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549 28869591) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)	Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		50 interacting genes: AATK ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP1 CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NONO PHACTR3 PPP1R11 PPP1R12B PPP1R12C PPP1R16A PPP1R16B PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP1R9B PPP2R5C PRKAR2A PTK2 RB1 RORC SH2D4A SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9	8 interacting genes: MEIS1 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1
Entrez ID		5500	3195
HPRD ID		11792	01728
Ensembl ID		ENSG00000213639	ENSG00000107807
Uniprot IDs		P62140 V9HW04	P31314
PDB IDs
Enriched GO Terms of Interacting Partners?
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