TLX1 and MEIS1

Data Source:
HPRD (in vitro)

		TLX1	MEIS1
Description		T cell leukemia homeobox 1	Meis homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of Transcription By RNA Polymerase II Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)	Adolescent idiopathic scoliosis ( 28334814) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Insomnia ( 27992416 32332799) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) PR interval ( 30679814 30046033 32439900 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		8 interacting genes: MEIS1 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3195	4211
HPRD ID		01728	03442
Ensembl ID		ENSG00000107807	ENSG00000143995
Uniprot IDs		P31314	O00470
PDB IDs			4XRS 5EGO
Enriched GO Terms of Interacting Partners?
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