PINX1 and EIF1AD

Data Source:
BioGRID (two hybrid)

		PINX1	EIF1AD
Description		PIN2 (TERF1) interacting telomerase inhibitor 1	eukaryotic translation initiation factor 1A domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus	Translational Initiation
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 32888494) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) White blood cell count ( 32888494 27863252)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Serum uric acid levels ( 32271837)
Interacting Genes		16 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TLK1 TNPO2 TP63 UBL5	34 interacting genes: AP2M1 BEND7 CCDC106 CEP55 CEP76 DPPA2 GAS8 GCSAML GLYR1 GTF2H4 LNX1 MEOX2 MID2 MREG PAX6 PBX4 PICK1 PINX1 RASSF10 RBAK RBM48 SDCBP SDCBP2 STAT1 STX11 TBC1D5 TEPSIN TLE5 TNNI1 ZBTB14 ZBTB8A ZNF280A ZNF521 ZNF558
Entrez ID		54984	84285
HPRD ID		05934	14411
Ensembl ID		ENSG00000254093	ENSG00000175376
Uniprot IDs		Q96BK5	A0A024R5B9 Q8N9N8
PDB IDs			2DGY
Enriched GO Terms of Interacting Partners?
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