GRM3 and PPM1A

Data Source:
HPRD (in vitro)

		GRM3	PPM1A
Description		glutamate metabotropic receptor 3	protein phosphatase, Mg2+/Mn2+ dependent 1A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendritic Spine Astrocyte Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity Scaffold Protein Binding	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Regulation Of Synaptic Transmission, Glutamatergic	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Negative Regulation Of SMAD Protein Complex Assembly Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs		LY2140023
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN	37 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		2913	5494
HPRD ID		03070	16199
Ensembl ID		ENSG00000198822	ENSG00000100614
Uniprot IDs		A4D1D0 Q14832	A0A024R6A5 B2R8E4 P35813
PDB IDs		1S8M 3SM9 4XAR 5CNK 5CNM 6B7H	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?
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