CHTF8 and EIF4EBP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHTF8	EIF4EBP1
Description		chromosome transmission fidelity factor 8	eukaryotic translation initiation factor 4E binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Ctf18 RFC-like Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	DNA Clamp Loader Activity Single-stranded DNA Helicase Activity	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	DNA Replication Mitotic Sister Chromatid Cohesion DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation
Pathways		Polymerase switching on the C-strand of the telomere	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)	Menopause (age at onset) ( 29773799)
Interacting Genes		6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4	38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		54921	1978
HPRD ID		16797	03746
Ensembl ID		ENSG00000168802	ENSG00000187840
Uniprot IDs		P0CG13	Q13541
PDB IDs			1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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