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FBXL12 and CDKN1C
Data Source:
HPRD
(in vivo)
FBXL12
CDKN1C
Description
F-box and leucine rich repeat protein 12
cyclin dependent kinase inhibitor 1C
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
SCF Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Molecular Function
Protein Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein-containing Complex Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Post-translational Protein Modification
Regulation Of Cell Cycle
Cell Cycle Arrest
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Pathways
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Cyclin D associated events in G1
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
Beckwith-Wiedemann syndrome
Adrenal carcinoma
GWAS
Pursuit maintenance gain (
29064472
)
Birth weight (
31043758
)
Calcium levels (
20705733
)
Malaria (
31844061
)
Interacting Genes
19 interacting genes:
A2M
ALDH3A1
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FBF1
FXYD3
GEMIN4
LNX1
MAST1
PSEN1
PSEN2
PSME3
RNF32
SMAD1
TGFBR1
UBE2D3
10 interacting genes:
AKT1
CCNE2
CDK4
FBXL12
LIMK1
MYOD1
NR4A2
PCNA
RB1
SKP2
Entrez ID
54850
1028
HPRD ID
12363
02913
Ensembl ID
ENSG00000127452
ENSG00000129757
Uniprot IDs
Q9NXK8
P49918
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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