Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FBXL12 and PSEN2
Data Source:
BioGRID
(two hybrid)
FBXL12
PSEN2
Description
F-box and leucine rich repeat protein 12
presenilin 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
SCF Ubiquitin Ligase Complex
Golgi Membrane
Kinetochore
Nucleus
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Growth Cone
Neuromuscular Junction
Protein-containing Complex
Ciliary Rootlet
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Molecular Function
Protein Binding
Endopeptidase Activity
Protein Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Post-translational Protein Modification
Regulation Of Cell Cycle
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Ephrin Receptor Signaling Pathway
Amyloid-beta Metabolic Process
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Drugs
Diseases
Alzheimer's disease (AD)
GWAS
Pursuit maintenance gain (
29064472
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
19 interacting genes:
A2M
ALDH3A1
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FBF1
FXYD3
GEMIN4
LNX1
MAST1
PSEN1
PSEN2
PSME3
RNF32
SMAD1
TGFBR1
UBE2D3
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
54850
5664
HPRD ID
12363
02860
Ensembl ID
ENSG00000127452
ENSG00000143801
Uniprot IDs
Q9NXK8
P49810
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?