MED18 and MED31

Data Source:
HPRD (in vivo)

		MED18	MED31
Description		mediator complex subunit 18	mediator complex subunit 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mediator Complex Core Mediator Complex	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription Protein Ubiquitination	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		9 interacting genes: AFMID CAMK2B HOMEZ MED20 MED31 MED9 TEPSIN TRIM39 USP49	59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		54797	51003
HPRD ID		17476	14382
Ensembl ID		ENSG00000130772	ENSG00000108590
Uniprot IDs		Q9BUE0	Q9Y3C7
PDB IDs
Enriched GO Terms of Interacting Partners?
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