DNAJB12 and CCR1

Data Source:
BioGRID (genetic interference)

		DNAJB12	CCR1
Description		DnaJ heat shock protein family (Hsp40) member B12	C-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Nuclear Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Hsp70 Protein Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Viral Process Ubiquitin-dependent ERAD Pathway Cellular Protein-containing Complex Assembly ERAD Pathway Chaperone Cofactor-dependent Protein Refolding Cellular Response To Misfolded Protein	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		1 interacting genes: FBXO7	29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		54788	1230
HPRD ID		07086	03101
Ensembl ID		ENSG00000148719	ENSG00000163823
Uniprot IDs		J3KPS0 Q9NXW2	P32246 Q5U003
PDB IDs		2CTP	1Y5D
Enriched GO Terms of Interacting Partners?
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