UGT1A1 and COPZ1

Data Source:
BioGRID (unspecified method)

		UGT1A1	COPZ1
Description		UDP glucuronosyltransferase family 1 member A1	COPI coat complex subunit zeta 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm Cytochrome Complex	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol COPI Vesicle Coat Transport Vesicle
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Liver Development Bilirubin Conjugation Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Animal Organ Regeneration Response To Lipopolysaccharide Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport
Pathways		Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Fostamatinib
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Bilirubin levels ( 22085899 31801373 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)	Blood protein levels ( 29875488) Chronotype ( 30696823) Hematocrit ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Meat-related diet ( 32066663) Platelet count ( 23263863 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	6 interacting genes: APP COPG1 COPG2 TMED10 TMED9 UGT1A1
Entrez ID		54658	22818
HPRD ID		08933	16738
Ensembl ID		ENSG00000241635	ENSG00000111481
Uniprot IDs		P22309 Q5DT03	A0A024RB72 P61923
PDB IDs			2HF6 5MC7
Enriched GO Terms of Interacting Partners?
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