COPZ1 and UGT1A1

Data Source:
BioGRID (unspecified method)

		COPZ1	UGT1A1
Description		COPI coat complex subunit zeta 1	UDP glucuronosyltransferase family 1 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol COPI Vesicle Coat Transport Vesicle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm Cytochrome Complex
	Molecular Function		Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport	Liver Development Bilirubin Conjugation Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Animal Organ Regeneration Response To Lipopolysaccharide Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia
Drugs			Fostamatinib
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Blood protein levels ( 29875488) Chronotype ( 30696823) Hematocrit ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Meat-related diet ( 32066663) Platelet count ( 23263863 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bilirubin levels ( 22085899 31801373 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		6 interacting genes: APP COPG1 COPG2 TMED10 TMED9 UGT1A1	3 interacting genes: COPZ1 SEC23B UGDH
Entrez ID		22818	54658
HPRD ID		16738	08933
Ensembl ID		ENSG00000111481	ENSG00000241635
Uniprot IDs		A0A024RB72 P61923	P22309 Q5DT03
PDB IDs		2HF6 5MC7
Enriched GO Terms of Interacting Partners?
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