UGT1A1 and SEC23B

Data Source:
BioGRID (unspecified method)

		UGT1A1	SEC23B
Description		UDP glucuronosyltransferase family 1 member A1	SEC23 homolog B, COPII coat complex component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm Cytochrome Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding
	Biological Process	Liver Development Bilirubin Conjugation Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Animal Organ Regeneration Response To Lipopolysaccharide Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Intracellular Protein Transport Positive Regulation Of GTPase Activity COPII-coated Vesicle Cargo Loading
Pathways		Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia
Drugs		Fostamatinib
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	Congenital dyserythropoietic anemias (CDAs)
GWAS		Bilirubin levels ( 22085899 31801373 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)	Refractive error ( 32231278)
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	25 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 RIN1 SEC23A SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UGT1A1
Entrez ID		54658	10483
HPRD ID		08933	11543
Ensembl ID		ENSG00000241635	ENSG00000101310
Uniprot IDs		P22309 Q5DT03	A0A2R8YFH5 Q15437
PDB IDs
Enriched GO Terms of Interacting Partners?
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