KRT20 and PIK3R2

Data Source:
BioGRID (two hybrid)

		KRT20	PIK3R2
Description		keratin 20	phosphoinositide-3-kinase regulatory subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Phosphotyrosine Residue Binding Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Cellular Response To Starvation Keratinization Intermediate Filament Organization Regulation Of Protein Secretion Cornification	Cellular Glucose Homeostasis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Protein Transport Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling
Pathways		Keratinization Formation of the cornified envelope	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction Rho GTPase cycle PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants
Drugs			Isoprenaline SF1126
Diseases
GWAS		Height ( 19893584)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		46 interacting genes: ABI2 AMOTL2 ANKRD36BP1 BBLN BCAS2 CCDC196 CCDC85B COASY CYSRT1 DES EIF4E2 EXOC8 FXR2 KRT13 KRT15 KRT24 KRT27 KRT3 KRT31 KRT34 KRT40 KRT72 KRT75 KRT76 KRT80 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP6-3 NOTCH2NLA NUP62 PIK3R2 PLEKHA5 PPP1R13B PRC1 PRPH SNAPIN TFIP11 TXLNA USHBP1 VIM WASHC1 ZC2HC1C ZC3H14	59 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		54474	5296
HPRD ID		12193	04404
Ensembl ID		ENSG00000171431	ENSG00000105647
Uniprot IDs		P35900	O00459
PDB IDs			2KT1 2XS6 3MTT 3O5Z 6OX7 6U28
Enriched GO Terms of Interacting Partners?
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