POR and CYP2C19

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		POR	CYP2C19
Description		cytochrome p450 oxidoreductase	cytochrome P450 family 2 subfamily C member 19
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Flavin Adenine Dinucleotide Binding NADP Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding (R)-limonene 6-monooxygenase Activity Aromatase Activity
	Biological Process	Xenobiotic Metabolic Process Response To Hormone Positive Regulation Of Monooxygenase Activity Cellular Organofluorine Metabolic Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Heterocycle Metabolic Process Omega-hydroxylase P450 Pathway
Pathways		Cytochrome P450 - arranged by substrate type	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate	Isoniazid Benzbromarone
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31959922 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)	Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Clozapine-to-N-desmethylclozapine metabolic ratio in schizophrenia ( 32555152) Diastolic blood pressure ( 27841878 27618448) Mean arterial pressure ( 27618448) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878 30578418) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828)
Interacting Genes		15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6	1 interacting genes: POR
Entrez ID		5447	1557
HPRD ID		00485	00486
Ensembl ID		ENSG00000127948	ENSG00000165841
Uniprot IDs		P16435	P33261
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6	4GQS
Enriched GO Terms of Interacting Partners?
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