POR

Description		cytochrome p450 oxidoreductase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Xenobiotic Metabolic Process Response To Hormone Positive Regulation Of Monooxygenase Activity Cellular Organofluorine Metabolic Process
Pathways		Cytochrome P450 - arranged by substrate type
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31959922 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)
Novel Interacting Genes		6 novel interacting genes: EHMT2 PSPHP1 RPS4X SIN3B SLC39A2 TGFBI
Interacting Genes		15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6
Entrez ID		5447
HPRD ID		00485
Ensembl ID		ENSG00000127948
Uniprot IDs		P16435
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
Enriched GO Terms of Interacting Partners?
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