CYP2C19

Description		cytochrome P450 family 2 subfamily C member 19
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding (R)-limonene 6-monooxygenase Activity Aromatase Activity
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Heterocycle Metabolic Process Omega-hydroxylase P450 Pathway
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs		Isoniazid Benzbromarone
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Clozapine-to-N-desmethylclozapine metabolic ratio in schizophrenia ( 32555152) Diastolic blood pressure ( 27841878 27618448) Mean arterial pressure ( 27618448) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878 30578418) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828)
Interacting Genes		1 interacting genes: POR
Entrez ID		1557
HPRD ID		00486
Ensembl ID		ENSG00000165841
Uniprot IDs		P33261
PDB IDs		4GQS
Enriched GO Terms of Interacting Partners?
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