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POLR2L and CHEK2
Data Source:
BioGRID
(two hybrid)
POLR2L
CHEK2
Description
RNA polymerase II, I and III subunit L
checkpoint kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
RNA Polymerase I Complex
Cytosol
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
PML Body
Molecular Function
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase I
Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Positive Regulation Of Type I Interferon Production
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
TRNA Transcription By RNA Polymerase III
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
DNA Damage Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Phosphorylation
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Peptidyl-serine Phosphorylation
Cellular Response To Drug
Regulation Of Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Cellular Protein Catabolic Process
Mitotic DNA Damage Checkpoint
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Protein Stabilization
Cell Division
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Gamma Radiation
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Mitotic Spindle Assembly
Replicative Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Response To Glycoside
Cellular Response To Bisphenol A
Negative Regulation Of DNA Damage Checkpoint
Positive Regulation Of Anoikis
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
XL844
Enzastaurin
Fostamatinib
Diseases
Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS
Pulse pressure (
30578418
)
Breast cancer (
29059683
23535729
)
Breast size (
22747683
)
Esophageal cancer (squamous cell) (
22960999
)
Esophageal cancer and gastric cancer (
20729852
)
Esophageal squamous cell carcinoma (
25129146
)
Essential hypertension (time to event) (
32589924
)
Glaucoma (
31959993
)
Glaucoma (primary open-angle) (
29891935
)
Immature fraction of reticulocytes (
32888494
)
Lung cancer (
24880342
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean reticulocyte volume (
32888494
)
Menopause (age at onset) (
26414677
)
Myeloproliferative neoplasms (
33057200
)
Optic cup area (
25631615
31798171
28073927
)
Optic disc area (
31798171
28073927
)
Optic disc size (
31809533
)
Pancreatic cancer (
25086665
)
Plateletcrit (
32888494
27863252
)
Prostate cancer (
29117387
)
Red cell distribution width (
32888494
28957414
)
Vertical cup-disc ratio (
20548946
31798171
25241763
28073927
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
28 interacting genes:
AGR2
BANP
CCDC85B
CCN3
CHEK2
COIL
EXOSC5
FAM217B
L3MBTL3
NACC1
NFKBIB
PHC2
POLR2A
POLR2B
POLR2C
POLR2D
POLR2E
POLR2G
POLR2H
PSMA6
REL
RPAP1
SNX7
SPAG5
THAP1
TP53BP2
TRIP13
ZBTB14
80 interacting genes:
AATF
APP
ARHGAP1
ASF1A
ATM
ATR
BAALC
BEX1
BRCA1
BRCA2
CCL5
CDC25A
CDC25C
CDH13
CDK11B
CDKN1A
CYP17A1
DAPK3
DBF4
DIRAS3
E2F1
ELAVL1
ENO1
ERCC6
FHL1
FHL3
FOXM1
GNAS
HMGN1
HOXC6
ITIH5
KLK7
KLK9
KPNA2
LATS2
LYPD3
MAPT
MDC1
MDM2
MDM4
MRC1
MSH2
MUS81
NBN
NR4A1
NSD3
PLK1
PLK3
POLR2L
PPM1D
PPP2CA
PPP2R2A
PPP2R2B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
PRDM14
PRKDC
PRMT2
PSMC3IP
PSME3
RAD9A
RCHY1
REV3L
RHOBTB2
RNF8
SIAH2
SLC25A6
SRPK1
SRPK2
ST14
STMN1
STRAP
TLR3
TP53
TSSK1B
USP39
VHL
Entrez ID
5441
11200
HPRD ID
01155
05084
Ensembl ID
ENSG00000177700
ENSG00000183765
Uniprot IDs
P62875
O96017
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
1GXC
2CN5
2CN8
2W0J
2W7X
2WTC
2WTD
2WTI
2WTJ
2XBJ
2XK9
2XM8
2XM9
2YCF
2YCQ
2YCR
2YCS
2YIQ
2YIR
2YIT
3I6U
3I6W
3VA4
4A9R
4A9S
4A9T
4A9U
4BDA
4BDB
4BDC
4BDD
4BDE
4BDF
4BDG
4BDH
4BDI
4BDJ
4BDK
Enriched GO Terms of Interacting Partners
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