CHEK2 and USP39

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		CHEK2	USP39
Description		checkpoint kinase 2	ubiquitin specific peptidase 39
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Peptidyl-serine Phosphorylation Cellular Response To Drug Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Negative Regulation Of Cell Cycle Arrest Cellular Response To Gamma Radiation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Protein Phosphopantetheinylation Cell Division
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	mRNA Splicing - Major Pathway
Drugs		XL844 Enzastaurin Fostamatinib
Diseases		Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Breast cancer ( 29059683 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 32888494 28957414) Vertical cup-disc ratio ( 20548946 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Neurofibrillary tangles ( 31497858)
Interacting Genes		80 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL	14 interacting genes: ACVR1 APP CHEK2 LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8
Entrez ID		11200	10713
HPRD ID		05084	07165
Ensembl ID		ENSG00000183765	ENSG00000168883
Uniprot IDs		O96017	A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	3JCR 6AH0 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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