TERF2IP and MT3

Data Source:
BioGRID (two hybrid)

		TERF2IP	MT3
Description		TERF2 interacting protein	metallothionein 3
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Mre11 Complex Shelterin Complex	Nucleus Cytoplasm Cytosol Synaptic Vesicle Inclusion Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Protein Kinase Activator Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cadmium Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Cholesterol Catabolic Process Zinc Ion Transport Cellular Metal Ion Homeostasis Cellular Zinc Ion Homeostasis Apoptotic Process Response To Metal Ion Detoxification Of Copper Ion Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Necrotic Cell Death Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Astrocyte Development Histone Modification Removal Of Superoxide Radicals Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Response To Food Activation Of Protein Kinase B Activity Leptin-mediated Signaling Pathway Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Stabilization Negative Regulation Of Oxidoreductase Activity Zinc Ion Homeostasis Cadmium Ion Homeostasis Regulation Of Protein Glycosylation Negative Regulation Of Necrotic Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion Cellular Response To Hypoxia Cellular Response To Nitric Oxide Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Oxygen Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Metallothioneins bind metals Metallothioneins bind metals
Drugs			Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		128 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 GAGE5 GAMT GNMT GPKOW H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	2 interacting genes: TERF2IP TTR
Entrez ID		54386	4504
HPRD ID		05452	00752
Ensembl ID		ENSG00000166848	ENSG00000087250
Uniprot IDs		Q9NYB0	A0A024R6R7 P25713
PDB IDs		1FEX 3K6G 4RQI	2F5H 2FJ4 2FJ5
Enriched GO Terms of Interacting Partners?
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