TERF2IP and ADA

Data Source:
BioGRID (two hybrid)

		TERF2IP	ADA
Description		TERF2 interacting protein	adenosine deaminase
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Mre11 Complex Shelterin Complex	Extracellular Space Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Vesicle Lumen
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Cell Adhesion Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Purine salvage
Drugs			Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases			T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233)
Interacting Genes		128 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 GAGE5 GAMT GNMT GPKOW H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	11 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2
Entrez ID		54386	100
HPRD ID		05452	00038
Ensembl ID		ENSG00000166848	ENSG00000196839
Uniprot IDs		Q9NYB0	A0A0S2Z381 F5GWI4 P00813
PDB IDs		1FEX 3K6G 4RQI	1M7M 3IAR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?