POLE2 and SAV1

Data Source:
BioGRID (affinity chromatography technology)

		POLE2	SAV1
Description		DNA polymerase epsilon 2, accessory subunit	salvador family WW domain containing protein 1
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GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Dendrite
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding Identical Protein Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Hair Follicle Development Apoptotic Process Signal Transduction Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Population Maintenance
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Signaling by Hippo
Drugs		Cladribine
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	5 interacting genes: EP300 NEDD4 RASSF1 STK3 STK4
Entrez ID		5427	60485
HPRD ID		16007	06229
Ensembl ID		ENSG00000100479	ENSG00000151748
Uniprot IDs		P56282	B3KTQ1 Q9H4B6
PDB IDs		2V6Z 5VBN	6AO5
Enriched GO Terms of Interacting Partners?
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