ADAM22 and LGI1

Data Source:
HPRD (in vitro)

		ADAM22	LGI1
Description		ADAM metallopeptidase domain 22	leucine rich glioma inactivated 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Extracellular Space Synaptic Cleft Glutamatergic Synapse
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		LGI-ADAM interactions	LGI-ADAM interactions
Drugs
Diseases			Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)
GWAS		Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Response to perphenazine in schizophrenia ( 29503163)
Interacting Genes		6 interacting genes: APP EPS8 LGI1 RAC2 YWHAB YWHAZ	1 interacting genes: ADAM22
Entrez ID		53616	9211
HPRD ID		04751	05216
Ensembl ID		ENSG00000008277	ENSG00000108231
Uniprot IDs		Q08AL8 Q9P0K1	A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970
PDB IDs		3G5C 5Y2Z 5Y31	5Y2Z 5Y30 5Y31
Enriched GO Terms of Interacting Partners?
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