ADAM22 and EPS8

Data Source:
BioGRID (two hybrid)

		ADAM22	EPS8
Description		ADAM metallopeptidase domain 22	epidermal growth factor receptor pathway substrate 8
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways		LGI-ADAM interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		6 interacting genes: APP EPS8 LGI1 RAC2 YWHAB YWHAZ	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		53616	2059
HPRD ID		04751	02563
Ensembl ID		ENSG00000008277	ENSG00000151491
Uniprot IDs		Q08AL8 Q9P0K1	B4E3T6 Q12929
PDB IDs		3G5C 5Y2Z 5Y31	2E8M
Enriched GO Terms of Interacting Partners?
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