PLCB2 and FAM98B

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		PLCB2	FAM98B
Description		phospholipase C beta 2	family with sequence similarity 98 member B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle TRNA-splicing Ligase Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding	RNA Binding Protein Binding Protein Methyltransferase Activity Identical Protein Binding
	Biological Process	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	tRNA processing in the nucleus
Drugs
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)	Psychosis (atypical) ( 24132900) Systemic lupus erythematosus ( 24871463)
Interacting Genes		7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7	20 interacting genes: MIR106A MIR10B MIR138-1 MIR141 MIR16-1 MIR18B MIR199A2 MIR200B MIR200C MIR205 MIR222 MIR34A MIR7-3 MIR9-1 MIRLET7A1 MIRLET7A2 MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G
Entrez ID		5330	283742
HPRD ID		04985	08786
Ensembl ID		ENSG00000137841	ENSG00000171262
Uniprot IDs		Q00722 Q59F77 Q9BVT6	Q52LJ0
PDB IDs		2FJU 2ZKM
Enriched GO Terms of Interacting Partners?
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