ATP6V0B and CCL19

Data Source:
BioGRID (affinity chromatography technology)

		ATP6V0B	CCL19
Description		ATPase H+ transporting V0 subunit b	C-C motif chemokine ligand 19
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Extracellular Region Extracellular Space
	Molecular Function	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication G Protein-coupled Receptor Signaling Pathway Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Tiludronic acid
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	8 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13 MEOX2 PF4V1
Entrez ID		533	6363
HPRD ID		04759	03750
Ensembl ID		ENSG00000117410	ENSG00000172724
Uniprot IDs		E9PNL3 Q99437	Q6IBD6 Q99731
PDB IDs			2MP1
Enriched GO Terms of Interacting Partners?
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