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CCL19 and ACKR2
Data Source:
HPRD
(in vivo)
CCL19
ACKR2
Description
C-C motif chemokine ligand 19
atypical chemokine receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleoplasm
Early Endosome
Cytosol
Actin Filament
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Recycling Endosome
Molecular Function
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
CCR10 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Chemokine Receptor Activity
Scavenger Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Dendritic Cell Chemotaxis
Myeloid Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Cellular Calcium Ion Homeostasis
Inflammatory Response
Immune Response
Cell Communication
G Protein-coupled Receptor Signaling Pathway
Activation Of JUN Kinase Activity
Response To Virus
Positive Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Neutrophil Chemotaxis
T Cell Costimulation
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Prostaglandin E
Positive Regulation Of T Cell Proliferation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Endocytosis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Cell Projection Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Response To Nitric Oxide
Positive Regulation Of Neutrophil Chemotaxis
Mature Conventional Dendritic Cell Differentiation
Cellular Response To Virus
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cell Motility
Positive Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Endocytosis
Chemotaxis
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Multicellular Organism Development
Calcium-mediated Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Chemokine receptors bind chemokines
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Rheumatoid arthritis (
30423114
24390342
)
Blood protein levels (
29875488
28240269
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Eotaxin levels (
27989323
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte chemoattractant protein-1 levels (
27989323
)
Monocyte count (
29403010
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Sum basophil neutrophil counts (
27863252
)
Sum eosinophil basophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
32888494
27863252
)
Interacting Genes
8 interacting genes:
ACKR2
ACKR4
CCL22
CCR10
CCR7
CXCL13
MEOX2
PF4V1
24 interacting genes:
APP
CCL11
CCL13
CCL14
CCL19
CCL2
CCL21
CCL25
CCL27
CCL28
CCL3
CCL3L3
CCL4
CCL5
CCL7
CCL8
CREB3
EFNA5
GJA8
MS4A1
NIPAL4
SACM1L
SLC13A4
TMEM167B
Entrez ID
6363
1238
HPRD ID
03750
09095
Ensembl ID
ENSG00000172724
ENSG00000144648
Uniprot IDs
Q6IBD6
Q99731
A1LP82
O00590
PDB IDs
2MP1
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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