PITX2 and KRTAP19-5

Data Source:
BioGRID (two hybrid)

		PITX2	KRTAP19-5
Description		paired like homeodomain 2	keratin associated protein 19-5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Cytosol Intermediate Filament
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Embryonic Heart Tube Left/right Pattern Formation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Keratinization
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors	Keratinization
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)
Interacting Genes		36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS TEX37 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3	97 interacting genes: ANKHD1 APOBEC1 ARID5A ATN1 ATPAF2 BHLHE40 C11orf16 C9orf24 CAMK2A CAMK2B CATSPER1 CCDC17 CELF5 CHRD COL8A1 CRACR2A CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRT3 DMRTB1 EFEMP2 ENKD1 ESRP1 EVX2 FAM168A FAM214B GLIS2 GLYCTK GPANK1 GRINA GUCD1 HAPLN2 HGS HOXB9 HYPK INCA1 KIFC3 KPRP KRT34 KRTAP12-4 KRTAP15-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MAPK1IP1L MGAT5B MYOZ3 MYPOP OIP5 OLIG3 OXER1 P4HA3 PATZ1 PITX1 PITX2 PLSCR4 POU2AF1 PPP1R16A PPP1R32 PRKAG3 PRPF31 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSMB2 PSMB4 RBPMS RBPMS2 RHOXF2 RNF38 RNF44 RTP5 RUSC1 SEMA3B SNRPC SOHLH1 TCF7L2 TEKT3 TEX37 TLE5 TNIP1 TSPYL6 UBQLN2 VAC14 VEZF1 VPS37C ZBTB32 ZIC1 ZNF414
Entrez ID		5308	337972
HPRD ID		03328	11209
Ensembl ID		ENSG00000164093	ENSG00000186977
Uniprot IDs		Q99697	Q3LI72
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?
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