PITX2 and ZNHIT3

Data Source:
BioGRID (two hybrid)

		PITX2	ZNHIT3
Description		paired like homeodomain 2	zinc finger HIT-type containing 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Nucleus Cytoplasm Pre-snoRNP Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Metal Ion Binding Thyroid Hormone Receptor Binding
	Biological Process	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Embryonic Heart Tube Left/right Pattern Formation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Box C/D SnoRNP Assembly Regulation Of Transcription, DNA-templated SnoRNA Localization
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)	Body mass index ( 26426971) Multiple sclerosis ( 31604244) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS TEX37 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3	14 interacting genes: CSNK2A2 ESR2 FCMR HNF4A MBNL1 MEIS2 NUFIP1 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24
Entrez ID		5308	9326
HPRD ID		03328	05139
Ensembl ID		ENSG00000164093	ENSG00000273611
Uniprot IDs		Q99697	A0A024R0X8 Q15649
PDB IDs		2L7F 2L7M 2LKX	2YQQ 5L85
Enriched GO Terms of Interacting Partners?
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