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BRCA1 and EP300
Data Source:
HPRD
(in vitro, in vivo)
BRCA1
EP300
Description
BRCA1 DNA repair associated
E1A binding protein p300
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Lateral Element
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Gamma-tubulin Ring Complex
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
Ribonucleoprotein Complex
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytosol
Protein-DNA Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
RNA Polymerase Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Transferase Activity, Transferring Acyl Groups
Chromatin DNA Binding
Activating Transcription Factor Binding
Nuclear Hormone Receptor Binding
Tau Protein Binding
Androgen Receptor Binding
NF-kappaB Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
Postreplication Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase III
Fatty Acid Biosynthetic Process
Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Chromosome Segregation
Centrosome Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Dosage Compensation By Inactivation Of X Chromosome
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Histone Acetylation
Negative Regulation Of Histone Acetylation
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Response To Estrogen
Regulation Of DNA Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Protein Autoubiquitination
Negative Regulation Of G0 To G1 Transition
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Tumor Necrosis Factor
Cellular Response To Indole-3-methanol
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Glycolytic Process
Transcription-coupled Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Animal Organ Morphogenesis
Regulation Of Autophagy
Macrophage Derived Foam Cell Differentiation
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
Viral Process
Histone Acetylation
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Positive Regulation Of Protein Binding
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Swimming
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Peptidyl-lysine Propionylation
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
Diseases
Breast cancer
Ovarian cancer
Rubinstein-Taybi syndrome
GWAS
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
28991256
25056061
29483656
)
Type 2 diabetes (
30297969
)
Interacting Genes
318 interacting genes:
ABL1
ABLIM3
ABRAXAS1
ACACA
ACTG1
ACTN3
AHR
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
C2CD6
CABYR
CASP3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERCC6
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPHLN1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
WDR6
WNT2B
WRN
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
374 interacting genes:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
AUTS2
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDK1
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EEF2
EGR1
EID1
EID2
ELF3
ELK1
ELL
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KDM2A
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCL1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MGMT
MITF
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX5
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIRT1
SIRT2
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNAI1
SNIP1
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF148
ZNF76
ZRANB2
Entrez ID
672
2033
HPRD ID
00218
04078
Ensembl ID
ENSG00000012048
ENSG00000100393
Uniprot IDs
A0A024R1V0
P38398
Q09472
Q7Z6C1
PDB IDs
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
6V8B
6V8K
6V8N
6V90
Enriched GO Terms of Interacting Partners
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