PIK3C2B and LTK

Data Source:
HPRD (in vivo)

		PIK3C2B	LTK
Description		phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	leukocyte receptor tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding Phosphatidylinositol Kinase Activity	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Biological_process Cellular Response To Starvation Phosphatidylinositol 3-kinase Signaling Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Autophagosome Organization	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Cellular Response To Retinoic Acid
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Breast cancer ( 23535733) Facial morphology ( 29921221) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30804560) Oily fish consumption ( 32066663) Peak expiratory flow ( 30804560) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)	High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		10 interacting genes: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 UBC YWHAQ	6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1
Entrez ID		5287	4058
HPRD ID		04160	01052
Ensembl ID		ENSG00000133056	ENSG00000062524
Uniprot IDs		A2RUF7 O00750 Q4LE65	P29376
PDB IDs
Enriched GO Terms of Interacting Partners?
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