LTK and PIK3C2B

Data Source:
HPRD (in vivo)

		LTK	PIK3C2B
Description		leukocyte receptor tyrosine kinase	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Receptor Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding Phosphatidylinositol Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Cellular Response To Retinoic Acid	Phosphatidylinositol Biosynthetic Process Biological_process Cellular Response To Starvation Phosphatidylinositol 3-kinase Signaling Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Autophagosome Organization
Pathways			Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Breast cancer ( 23535733) Facial morphology ( 29921221) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30804560) Oily fish consumption ( 32066663) Peak expiratory flow ( 30804560) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)
Interacting Genes		6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1	10 interacting genes: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 UBC YWHAQ
Entrez ID		4058	5287
HPRD ID		01052	04160
Ensembl ID		ENSG00000062524	ENSG00000133056
Uniprot IDs		P29376	A2RUF7 O00750 Q4LE65
PDB IDs
Enriched GO Terms of Interacting Partners?
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